The second USS Thresher (SSN-593) was the lead boat of her class of nuclear-powered attack submarines in the United States Navy. Her loss at sea in the North Atlantic during deep-diving tests approximately 220 miles east of Boston, Massachusetts, on 10 April 1963 was a watershed event for the U.S. Navy, leading to the implementation of a rigorous submarine safety program known as SUBSAFE. Judging by the 129 crew members and shipyard personnel who were killed in the incident, historic context and significance, the sinking of Thresher was then, and remains today, the world’s worst submarine disaster. This was the first U.S. nuclear submarine lost at sea.